The relationship of neutrophil/lymphocyte ratio (NLR) and C-reactive protein (CRP) parameters with mortality in intensive care unit (ICU) patients
Selen Zeliha Mart Komurcu 1 , Yakup Artik 2 * , Nevra Pelin Cesur 3 , Yavuz Uyar 4 , Yasemin Tuba Sutasir 1 , Elcin Akduman Alasehir 5 , Ebru Kaya 1
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1 Ministry of Health University of Health Science, Kanuni Sultan Süleyman Research and Training Hospital, 34303, Kücükcekmece, Istanbul, TURKEY2 Republic of Turkey, Ministry of Health, Health Institutes of Turkey (TUSEB), COVID‐19 Diagnostic Center, Istanbul Provincial Directorate of Health, University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital, 34303, Istanbul, Kucukcekmece, TURKEY3 Yildiz Technical University, Molecular Biology and Genetics Department, 34220, Esenler, Istanbul, TURKEY4 Tekirdağ Namık Kemal University, Faculty of Medicine, Department of Medical Microbiology, 59100, Tekirdağ, TURKEY5 Department of Medical Microbiology, Manisa Public Health Laboratory, Manisa, TURKEY* Corresponding Author


The neutrophil/lymphocyte ratio (NLR) is generally accepted as an indicator of sub-clinical inflammation. In recent studies, it has been found that the NLR can be used in the calculation of morbidity and mortality. Within the scope of this study, the relationship between NLR and mortality in hospitalized patients between January 1, 2015, and August 31, 2019, was explained. Among the studies on NLR between these dates, the age range of 584 patients with normal and abnormal C-reactive protein (CRP) values ​​ranged from 10 to 100, and the data of 272 female and 312 male patients were analyzed. In this study, while evaluating the academic contributions of the NLR and CRP data obtained with the retrospective approach to the literature in the cases of intensive care unit (ICU) patients. Age, NLR, CRP, IgG, and IgG percent levels of exitus group patients were significantly higher than non-exitus group (p<0.05). Lymphocyte level of non-exitus group (lymphocyte 1.26±1.04) was significantly higher (p<0.05) than exitus group (age, mean±SD 68.70±16.69, NLR 17.48±25.80, CRP 167.27±114.10, IgG 0.38±0.60, IgG percent 2.56±5.15, and neutrophile 12.50±9.68). We hypothesize that the data evaluated together with the immature granulocyte count will help and benefit the intensive care specialists in their evaluation reports for the patient.


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Article Type: Original Article

ELECTR J MED DENT STUD, 2022, Volume 12, Issue 4, Article No: em0101

Publication date: 08 Nov 2022

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